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These examples showcase the promise of this new enzyme class

19 There are multiple problems with the trials assessing the use of rifaximin, 20 such as confounding effects of transjugular intrahepatic portosystemic shunt (TIPS) and surgical portosystemic shunts, 17 randomization imbalance, 21,22 lack of benefit in high risk populations (such as in prevention of HE in those undergoing TIPS), 23 and absence of objective HE scales in outcome assessment in some of the studies

research grants from Asahi Kasei, Astellas, Mitsubishi Tanabe Pharma, Teijin Pharma, Boehringer Ingelheim Japan, Eli Lilly and Company, Novartis Pharma, Fuji Yakuhin, and Mochida Pharmaceutical

2020 Jun 30;15(1):170